2nd Edition, The Nemechek Protocol for Autism and Developmental Disorders: A How-To Guide For Restoring Neurological Function

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This variant results in increased IL1B, which can lead to neuroinflammation. This inflammation in the brain has been associated with decreased neurogenesis and increased stress, anxiety, and social interactions [ 57]. At this point, I’m considering switching from Nordic Naturals fish oil to NOW DHA capsules because the latter has more EPA, which is really important for adults. As for the extra virgin olive oil, I’m still at 2 tablespoons, which is what Dr. Nemechek recommends.

The maximum inulin dose for adults in 2 teaspoons, but you need to work up to that, and many people don’t need that much. When it comes to inulin, it’s sort of a “watch and see” approach because everyone’s gut conditions are unique.As with many supplements, olive oil is easy to adulterate, and many of the olive oil bottles you see on store shelves are not 100% pure olive oil. It’s critical to use only 100% pure extra virgin olive oil that’s certified by COOC.com. I usually belong to the camp that believes “If it sounds too good to be true, it probably is.” But when I read Dr. Nemechek’s research and ideas behind the protocol for SIBO, it made total sense. Dr. Nemechek believes that probiotics have the potential to increase the numbers of all bacteria, as opposed to just the “good” guys. While on this protocol, he advises to stop probiotic supplements, but fermented foods such as sauerkraut and kefir are fine. And yet, 8 months have flown by. Now I’m reaping the benefits so many others have experienced – benefits that I had previously only dreamed of.

This bacterial overgrowth damages the intestinal wall, releasing a substance called lipopolysaccharide (LPS) into our tissue. When our white blood cells notice the LPS, they react by releasing highly inflammatory cytokines into the blood. GSTP1 encodes one of the glutathione transferase enzymes. This enzyme is involved in the attachment of toxins, carcinogens, and drugs to a reduced glutathione molecule. Shank3 is a scaffolding protein that is densely associated with postsynaptic glutamatergic synapses and is an important part of the postsynaptic density (PSD), a specialized protein-dense structure attached to the postsynaptic membrane. It acts as a master organizer of the PSD because of its ability to interact with multiple key synaptic components, including glutamate receptor complexes, anchoring proteins, and the actin cytoskeleton [ 7]. SHANK3 is a critical orchestrator of frontocortical function. Disrupted connectivity of the prefrontal areas may underpin the socio-communicative impairments observed in SHANK3 mutation carriers [ 8]. Rather than working directly to increase levels of SHANK3 protein or affect stability, oxytocin is one such molecule that appears to work on downstream pathways such as long-term potentiation [ 35]. Increasing long-term potentiation (LTP) in multiple areas of the brain, including the hippocampus, has been shown to stimulate dendrite maturation and connectivity [ 36]. Decreased dendrite maturation is one of the possible downstream issues in individuals with SHANK3 deficiencies [ 9]. Due to its effects on LTP and its differential expression in the brain, oxytocin was also shown to decrease LTP-mediated pain hypersensitivity, often seen in individuals with ASD [ 36, 37]. I was diagnosed with celiac in 2020. It was a surprise to me as I’ve eaten gluten for most of my life without issue. I grew up in France and consumed pasta, baguettes, and beer weekly without problems. That changed when I turned 29. After a super-fun array of tests, including blood samples, a colonoscopy, and an endoscopy, my GI specialist broke the news: I had celiac disease.

What Is the Nemechek Protocol?

Another limitation to this study is the size of the database. Above, we present data from a handful of SHANK3 cases. While the authors have successfully applied this approach to several individuals with SHANK3 and many hundreds of individuals with other ASD-contributing genomic factors, it is still a relatively small dataset. Yes, I’ve been told MTHFR mutations can play a role in so many things. When I think about its far-reaching nature, it kinda makes my head spin! But it makes sense considering it’s our genes we’re talking about. The HLA-DQ2.5 variant has a conformation that leads to an increased immunological response to the presentation of gluten peptides. This is associated with an increased risk of developing celiac disease [ 62]. You’re probably wondering what The Nemechek Protocol is. Basically, it’s a nutrition/supplement protocol consisting of fish oil, olive oil, Inulin fiber, and an emphasis on avoiding Omega 6 oils.